The research projects in this cluster focus on the synthesis of novel, branched and dendritic polymer architectures, mostly based on -amino acid building blocks. The research projects do not aim at the synthesis of perfect (i.e. defect-free) dendrimers, but rather focus on the development of alternative, less time-consuming synthetic strategies towards branched polymer architectures. The interest in branched and dendritic poly(-amino acid)s (polypeptides) is two-fold. On the one hand, these compact, branched polymers may serve as structural mimics of globular proteins. On the other hand, highly-branched polypeptides may be interesting alternatives to perfect polypeptide dendrimers, which have received considerable attention as non-viral vectors for gene delivery and as platforms for the construction of magnetic resonance imaging agents.
. H.-A. Klok, J. Rodriguez-Hernnndez, Dendritic-graft polypeptides, Macromolecules, 2002, 35, 8718-8723
. J. Rodriguez-Hernandez, H.-A. Klok, Synthesis and ring-opening (co)polymerization of l-lysine N-carboxyanhydrides with labile side-chain protective groups, J. Polym. Sci., Part A: Polym. Chem. 2003,
41, 1167 – 1187.
. J. Rodriguez-Hernandez, M. Gatti, H.-A. Klok, Highly-branched poly(l-lysine), Biomacromolecules,
2003, 4, 249 – 258.
. A. Lübbert, T.Q. Nguyen, F. Sun, S.S. Sheiko, H.-A. Klok, L-Lysine dendronized polystyrene, Macromolecules 2005,
38, 2064 – 2071.